Thorne Research Methyl-Guard Plus

Selection: 90 Capsules
Sale price$51.00

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  • Thorne Research Methyl-Guard Plus provides support for heart, blood vessel, brain, nerve, and bone health.
  • Contains higher amounts of 5-MTHF (active folate), B6, B12.
  • Riboflavin 5'-phosphate added for extra homocysteine metabolism support.
  • Easy 3 capsules daily dosing*

Methylation – the addition of a methyl group (CH3 – one carbon attached to three hydrogens) to another molecule – is an essential and vital biochemical process within the human body that is involved in a large number of biochemical pathways involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. A number of specific nutrients are necessary for methylation to occur normally.

Methyl-Guard Plus contains higher amounts of 5-MTHF (the active form of folate), pyridoxal 5'-phosphate (active B6), and methylcobalamin (active B12), than our original Methyl-Guard. We have also added riboflavin 5'-phosphate (the active form of vitamin B2) for its positive effect on homocysteine metabolism and methylation.* These ingredients provide the necessary nutrients the body uses to push forward the process of methylation. Methyl-Guard Plus is more concentrated, so your patients will appreciate the recommended daily amount of three capsules, which will improve compliance. Our original Methyl-Guard is still available.

Suggested Use: Take 1-3 capsules daily or as recommended by your health practioner. 


Serving Size: Three Capsules

Three Capsules Contain......%DV

Riboflavin (as Riboflavin 5'-Phosphate Sodium) ......90 mg......  6,923%

Vitamin B6 (as Pyridoxal 5'-Phosphate) .....45 mg ...... 2,647%

Folate (3 mg as L-5-Methyltetrahydrofolatet from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)...... 5 mg DFE...... 1,250%

Vitamin B12 (as Methylcobalamin) ......3 mg..... 125,000%

Betaine Anhydrous (Trimethylglycine)...... 1.8 g

*Daily Value (DV) not established.

Other Ingredients:

Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.


This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

If pregnant, consult your health professional before using this product.

5-methyl-tetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

* These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to treat, mitigate, diagnose or cure any disease.

Customer Reviews

Based on 8 reviews
T K.
Best supplement for those with MTHFR genetic factor

This supplement allows one with the MTHFR factor to absorb B vitamins that otherwise could not be absorbed. Very good product. I notice a marked difference from standard B vitamins that are not methylated.

Lynn S.
Doing it’s job!

I have been using Methyl Guard Plus for several years now because I have MTHFR and will continue to do so.

Cynthia T.

powerful for your body.

Methyl Guard Plus

My son needs it for life glad it's available and natural

Maryann A.
Natural path likes it!

Natural path likes it!

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