Thorne Research Methyl-Guard Plus

9 reviews

Selection: 90 Capsules
Sale price$57.00

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  • Thorne Research Methyl-Guard Plus provides support for heart, blood vessel, brain, nerve, and bone health.
  • Contains higher amounts of 5-MTHF (active folate), B6, B12.
  • Riboflavin 5'-phosphate added for extra homocysteine metabolism support.
  • Easy 3 capsules daily dosing*

Methylation – the addition of a methyl group (CH3 – one carbon attached to three hydrogens) to another molecule – is an essential and vital biochemical process within the human body that is involved in a large number of biochemical pathways involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. A number of specific nutrients are necessary for methylation to occur normally.

Methyl-Guard Plus contains higher amounts of 5-MTHF (the active form of folate), pyridoxal 5'-phosphate (active B6), and methylcobalamin (active B12), than our original Methyl-Guard. We have also added riboflavin 5'-phosphate (the active form of vitamin B2) for its positive effect on homocysteine metabolism and methylation.* These ingredients provide the necessary nutrients the body uses to push forward the process of methylation. Methyl-Guard Plus is more concentrated, so your patients will appreciate the recommended daily amount of three capsules, which will improve compliance. Our original Methyl-Guard is still available.

Suggested Use: Take 1-3 capsules daily or as recommended by your health practioner. 


Serving Size: Three Capsules

Three Capsules Contain......%DV

Riboflavin (as Riboflavin 5'-Phosphate Sodium) ......90 mg......  6,923%

Vitamin B6 (as Pyridoxal 5'-Phosphate) .....45 mg ...... 2,647%

Folate (3 mg as L-5-Methyltetrahydrofolatet from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)...... 5 mg DFE...... 1,250%

Vitamin B12 (as Methylcobalamin) ......3 mg..... 125,000%

Betaine Anhydrous (Trimethylglycine)...... 1.8 g

*Daily Value (DV) not established.

Other Ingredients:

Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.


This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

If pregnant, consult your health professional before using this product.

5-methyl-tetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

* These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to treat, mitigate, diagnose or cure any disease.

Customer Reviews

Based on 9 reviews
Methyl guard

Great balance of the B Vit and in form usable by those of us unable to methylate

T K.
Best supplement for those with MTHFR genetic factor

This supplement allows one with the MTHFR factor to absorb B vitamins that otherwise could not be absorbed. Very good product. I notice a marked difference from standard B vitamins that are not methylated.

Lynn S.
Doing it’s job!

I have been using Methyl Guard Plus for several years now because I have MTHFR and will continue to do so.

Cynthia T.

powerful for your body.

Methyl Guard Plus

My son needs it for life glad it's available and natural

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