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Life Extension Optimized Folate (L-Methylfolate) is a bioactive folate and is up to seven times more bioavailable than folic acid.*
Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF).
Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine).
A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement.
5-MTHF has been shown to dramatically raise red blood cell folate concentration, an indicator of folate status181 compared with folic acid supplementation.