Bioclinic Naturals EstroVantage EM

Selection: 90 Vegetarian Capsules
Sale price$41.60

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  • Bioclinic Naturals EstroVantage EM, in general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17-estradiol. In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16a-hydroxyestrone (16a-OHE1).
  • Both 16a-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16a-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative. As such, an increased ratio 2-OHE:16a-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women.
  • Several natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events.
  • Other compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption. It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.
  • IGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%.
  • In a 34 patient randomized controlled trial foods enriched with bioactive compounds, including rosemary extract (Rosemarinus officinalis), were found to be a promising adjuvant therapy in advanced breast cancer patients.
  • Green tea polyphenols inhibit the proliferation of breast cancer cells in vivo and in vitro Silymarin can down-regulate gene products involved in the proliferation of tumor cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis (VEGF) and metastasis (adhesion molecules).
  • Curcumin inhibits human breast cancer cell growth by mediating certain signaling cascades including the modulation of the NF-kB signaling pathway.
  • Sulforaphane can inhibit the expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells, inhibiting proliferation and down-regulating hormone receptor expression.

Take 3 capsules per day taken with food or as directed by a health care professional. Consult a health care professional for use beyond 12 weeks.

Supplement Facts

Serving Size: 3 capsules

Amount Per Serving:

Calcium D-Glucarate ... 225mg
(d-glucaric acid calcium salt)

Indole-3-Carbinol ... 225mg

Green Tea Extract ... 150mg
(Camellia sinensis)(leaf)
(80% catchins, 45%EGCg <1% caffeine)

Tomato Extract ... 150mg
(Lycopersicon esculentum)(fruit)
(5% lycopene)

Broccoli Powder ... 83mg
(Brassica oleracea var. italica)(aerial)
(0.36% sulforaphane)

Turmeric Extract ... 75mg
(Curcuma longa)(root)
(95% curcuminoids)

Milk Thistle Extract ... 75mg
(Silybum marianum)(seed)
(60% silymarin)

DIM ... 75mg
(3, 3-diindolylmethane)

Rosemary Extract ... 38mg
(Rosmarinus officinalis)(leaf)

Other Ingredients

Vegetarian capsule (Carbohydrate gum [cellulose] purifed water), microcrystalline cellulose and magnesium stearate (vegetable grade).

* These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to treat, mitigate, diagnose or cure any disease.

Customer Reviews

Based on 1 review
Works great

I take this to help decrease breast cysts. It works great. My cysts are pretty much gone.

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