I have been using Douglas Cape Aloe 250 for years - it was highly suggested by a lady working in wellness. It is safe and gentle and the 250 dosage is easy to manage so you can take more or less as is needed. You will know if you take too much!!! Also the Douglas company is the only one I will order it from. I was purchasing it from Amazon by Douglas until it was no longer available but now that I know Douglas has a site to purchase from I'll be sticking with them directly. I also tried another company from Amazon that was 450 mg. It not only was not reliable but the 450 was impossible to manage.