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i-cool+D - Supplement for Hot Flashes and Bone Building

Menopause Relief Supplement Proven to Reduce Hot Flashes + Vitamin D for Bone Building - 45 Tablets


Retail Price: $34.99
Manufacturer: i-health

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  • i-cool+D is a non-hormonal menopause relief supplement proven to reduce hot flashes and night sweats with 1000 IU of vitamin D added for proven bone-building*.
  • Active ingredient geniVida® (non-soy genistein) is clinically proven to be effective as a hot flashes treatment in 9 out of 10 women*1-2.
  • Vitamin D has been shown to reduce bone loss, and the combination of vitamin D and calcium supplementation has been shown in clinical trials to result in significantly reduced fracture incidence*.
  • Pure genistein like geniVida® has been clinically proven to maintain bone mineral density and composition in post-menopausal women*.3
  • i-cool+D menopause supplement does not rely on black cohosh, which failed to relieve hot flashes and night sweats in a major clinical study funded by the National Institutes of Health4.
  • There are no side effects caused by taking i-cool+D as a hot flashes treatment.
  • Made under FDA mandated Supplement Good Manufacturing Practices.
  • i-cool+D does not contain synthetic estrogen, soy, or other allergens.



  1. Elliott et al. 2010. The effect of gensitein on menopause symptom management in healthy postmenopasual women: a multi-center, randomized, placebo-controlled study. 9th International Symposium on the Role of Soy in Health Promotion and Chronic disease Prevention and Treatment. Washington, DC, October 18.
  2. Evans et. al.The effect of synthetic gensitein on menopause symptom management in healthy post-menopausal women: A multi-center, randomized, placebo-controlled study. Maturitas 2011;68:189-96.
  3. Marini H. et al. 2008 Breast safety and efficacy of genistein aglycone in postmenopausal bone loss: A follow-up study. J Clin Endocrinol Metab 93(12):4787-4796.
  4. Newton KM et al. 2006 Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy or placebo: a randomized trial. Ann Intern Med 145(12);869-879. 

* These statements have not been evaluated by the U.S. food and Drug Administration. The product is not intended to treat, mitigate, diagnose or cure any disease.

Genistein Is the Safe and Effective Solution To Menopausal Symptoms


By Dr. James G. Elliott Ph.D.


Hot flashes are the most common symptom of menopause in 50-70% of menopausal women in developed countries and estrogen hormone replacement therapy is highly effective in alleviating these symptoms.  However, in recent years the use of estrogen hormone therapy has been substantially reduced due to the finding in the large Women’s Health Initiative study that it increases risk of stroke and breast cancer.  Thus, there is a need for a safe and non-hormonal alternative for hot flashes.  One of the most highly studied alternatives is soybean isoflavones. It was suspected that soybeans contain compounds to help reduce menopausal symptoms since Asian countries where soybean consumption is much higher than in Western counties only 20-25% of postmenopausal women experience hot flashes.


Soy isoflavones are naturally occurring in soybeans and consist of three compounds called genistein, daidzein, and glycitein which make up approximately 50%, 40%, and 10% of the total soybean isoflavone content, respectively. Since the mid 1990s, dozens of studies have been conducted with isoflavones to determine if they will alleviate menopausal symptoms. Yet the findings have been very mixed and it was it was proposed only recently that soy products with genistein as the predominate isoflavone were consistently effective and those with daidzein as the predominate isoflavone were mostly ineffective.  This proposal has now been confirmed in four clinical intervention studies with postmenopausal women given pure genistein.


Two studies were conducted in Sicily with postmenopausal women given a pure natural genistein extract for 1 and 2 years, respectively.  In the first study published in 2004 by Crisafulli and coauthors in the journal Menopause, 98 postmenopausal women suffering from approximately 5 hot flashes per day were given a daily dose of 54 mg of genistein or a placebo for 12 months. After 3, 6 and 12 months the women given genistein had statistically significant reductions by comparison to placebo of 22, 29 and 24%, respectively. The same group conducted a much larger study with 389 postmenopausal women over 2 years given 54 mg/day of genistein or a placebo.  The one year results published in 2007 by D’Anna and coauthors in Menopause showed effectiveness in the genistein group after one month which reached its peak after 12 months at 56.4% reduction in hot flashes.  The second year of the study published by D’Anna and coauthors in a 2009 issue of Menopause showed no further decrease after 24 months beyond the 56.4% decrease seen at 12 months. A third study also conducted in Italy by Albertazzi and coauthors and published in Climacteric in 2005 gave 90 mg/day of genistein or placebo to 100 postmenopausal women in a crossover study for 6 weeks.  Although there was no effect of genistein on hot flashes in the entire group, women who had more than 9 hot flashes per day had a 31.25% reduction in the genistein group compared to a 20% reduction in the placebo group.


A fourth clinical intervention study with a pure synthetic genistein was competed and reported by Elliott and coauthors in 2009 and is currently in press. In this placebo-controlled study 84 postmenopausal women received 30 mg of genistein or a placebo for 12 weeks.  After 12 weeks the women on genistein had a 51% reduction on hot flashes compared to only 27% for the women in the placebo, a highly significant difference.  Compared to placebo, this reduction in hot flashes at 12 weeks (51-27%) was a net reduction of 24% which is very similar to the 29% net reduction seen in the study of Crisafulli and coauthors.  What is particularly noteworthy about this study is that the dose was 30 mg versus 54 mg in the Sicily studies and a daily genistein intake of 30 mg falls well within the range consumed by Asians who eat traditional soy foods. The genistein used in this study is branded as geniVida®, a product of DSM Nutritional Products. It is 99% pure, soy-free, allergen-free and has an extensive package of safety studies in animals and humans which demonstrate it is safe for daily use.



The geniVida® used in the above study is now available in a new product for hot flash relief called i-cool. 



About the Author:

Dr. Elliott has been a clinical nutrition researcher in the food and nutritional supplement industries for over 40 years. During this time, Dr. Elliott has helped develop a number of the leading nutritional health products found on the market today.


Supplement Facts


Serving Size:   One (1) Tablet

Servings per Container:   45


Amount Per Serving                                                            % Daily Value

geniVida® non-soy genistein           30 mg                           **        


Vitamin D-3 (cholecalciferol          1000 mg                          250%

** Daily Value Not Established

Other Ingredients:

Microcystalline Cellulose, Dicalcium Phosphate, Croscarmellose Sodium, Stearic Acid (kosher), Hypromellose, Magnesium Silicate, Magnesium Stearate Vegetable, Titanium Dioxide and Silica.

i-cool + D is free of artificial dyes, color, preservatives, flavor, soy, yeast, wheat , gluten, lactose, sugar, starch or animal products.

Clinical Studies

  • In a recent high quality clinical study1, postmenopausal women experiencing at least 40 hot flashes per week when given 30 milligrams of genistein experienced a 51% reduction in the number of hot flashes by week 12 and significantly fewer hot flashes per day at weeks 8 and 12 versus the starting baseline.
  • A review of 11 human studies on hot flashes2 concluded that it was the genistein that is responsible for the reduction in hot flashes and not the other isoflavones found in soy.
  • In another high quality clinical study with pure genistein employing 389 postmenopausal women3 the average number of hot flashes was significantly decreased at 1, 3, 6 and 12 months with the average percent reduction reaching 56% by the 12-month point. No further reduction in hot flashes occurred after 12 months but the benefit was maintained.



  1. Elliott et al. 2010. The effect of gensitein on menopause symptom management in healthy postmenopasual women: a multi-center, randomized, placebo-controlled study. 9th International Symposium on the Role of Soy in Health Promotion and Chronic disease Prevention and Treatment. Washington, DC, October 18.
  2. Williamson-Hughes PS, Flickinger BD, Messina MJ, Empie MW. Isoflavone supplements containing predominantly genistein reduce hot flash symptoms: a critical review of published studies. Menopause 2006;13:831-839.
  3. D'Anna R, Cannata ML, Marini H, Atteritano M, Cancellieri F, Corrado F, Triolo O, Rizzo P, Russo S, Gaudio A, Frisina N, Bitto A, Polito F, Minutoli L, Altavilla D, Adamo EB, Squadrito F. Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 2-year randomized, double-blind, placebo-controlled study. Menopause 2009;16:301-306.

Q:  What is i-cool+D and what is it made from?

A:  i-cool+D is a clinically proven supplement that helps reduce hot flash, night sweats, mood swings, and other symptoms of menopause including irritability, difficulty in sleeping, dry or itchy eyes, vaginal dryness, poor skin tone, loss of interest in sex, difficulty in concentrating, feeling tired or lacking in energy, memory loss. i-cool+D relies on geniVida non-soy genistein and does not contain black cohosh, soy, estrogen, or other hormones.  i-cool+D is a safe and effective alternative to HRT. i-cool+ D also includes 1000 IU vitamin D for proven bone building. 

Q:  Why is Vitamin D included in a menopause product?

A:  Menopause is accompanied with a loss of bone mineral density that can ultimately lead to fractures. Vitamin D supplementation has been shown to reduce bone loss. Vitamin D supplementation in combination with calcium has been shown in clinical trials to significantly reduce the incidence of bone fractures. In addition to i-cool + D women should take 1000 mg of calcium per day to reduce the risk of bone loss.  


Q:  What is geniVida and genistein?

A:  Genistein is the most predominate isoflavone found in soy.  Pure genistein has been proven to reduce hot flashes and night sweats. geniVida brand genistein is not made from soy but it has an identical chemical structure.  This allows for all the benefits of genistein without the side effects and disadvantage of soy based genistein.


Q:  How do we know i-cool+D helps reduce menopause symptoms?

A:  Multiple double blind placebo controlled studies have been conducted with genistein.  These studies consistently found that menopausal women experience significant reduction in hot flashes and night sweats when taking genistein.  Another study showed 9 out of 10 women taking i-cool+D experienced a reduction in hot flashes.  Relief from other menopause symptoms was also observed.    


Q:  How long should I take i-cool+D before seeing results?

A:  While i-cool+D can work as quickly as one week, on average women experience a 30% decrease in hot flashes after taking i-cool+D for one month.  Studies have shown further reductions in hot flashes can occur for up to one year, after which the benefits remain the same. Bone loss is a silent but show process. The benefit of vitamin D supplementation will not be noticed for a year or longer and then only it a persons’ bone mineral density is being measured by their physician. 


Q:  Is it safe to take i-cool+D every day?

A:  Yes.  Numerous safety studies have been conducted on geniVida, the active ingredient in i-cool+D.  They have all shown that geniVida is safe when taken at the recommended dosage. Numerous studies have shown that vitamin D taken at the dose in i-cool + D is safe but toxicity can occur at very high doses.


Q:  How does i-cool+D work?

A:  During and after menopause, a woman’s estrogen levels drop.  This drop often brings on discomforting symptoms such as hot flashes, night sweats and mood changes, as well as the rapid loss of bone that can lead to bone health problems.  The pure genistein in i-cool+D combats this drop in estrogen and alleviates, if not eliminates, miserable menopausal symptoms. Furthermore, the Vitamin D in i-cool + D optimizes calcium absorption to replace the calcium loss during menopause.


Q:  How many pills should I take each day?
A:  You only need to take one tiny pill per day. i-cool+D can be taken in the morning or evening.  It is recommended you take i-cool+D at the same time each day.

Q:  Does i-cool+D contain estrogen or other hormones?

A:  No


Q:  Does i-cool+D contain soy?

A:  No.


Q:  Can women with allergies take i-cool+D?

A:  i-cool+D is free of artificial dyes and colors, preservatives, flavors, soy, yeast, wheat, gluten, lactose, sugar, starch and animal products.


Q:  If I’m allergic to soy, and geniVida is nature-identical to soy-based genistein, can I take i-cool+D?

A:  Yes, geniVida is non-soy genistein.


Q:  Does i-cool+D contain black cohosh?

A:  No.



Q:  Who makes i-cool+D?

A:  i-cool+D is manufactured by DSM, a Global life sciences company that has been in existence for over 100 years. DSM takes product, quality and efficacy very seriously.  They provide the very highest quality vitamins for the supplement, food, and beverage brands that people use every day in over 49 countries.


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